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TargetSerine/threonine-protein kinase Aurora-C
LigandBDBM50327912
Substrate/Competitorn/a
Meas. Tech.ChEMBL_665048
IC50 62±n/a nM
Citation Bindi, SFancelli, DAlli, CBerta, DBertrand, JACameron, ADCappella, PCarpinelli, PCervi, GCroci, VD'Anello, MForte, BGiorgini, MLMarsiglio, AMoll, JPesenti, EPittalà, VPulici, MRiccardi-Sirtori, FRoletto, FSoncini, CStorici, PVarasi, MVolpi, DZugnoni, PVianello, P Thieno[3,2-c]pyrazoles: a novel class of Aurora inhibitors with favorable antitumor activity. Bioorg Med Chem18:7113-20 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase Aurora-C
Name:Serine/threonine-protein kinase Aurora-C
Synonyms:Aurora kinase C | Aurora kinase C (AURKC) | Aurora-C | Aurora/Ipl1-related kinase 3 | Aurora/Ipl1/Eg2 protein 2 | Serine/threonine-protein kinase 13
Type:Enzyme
Mol. Mass.:35602.43
Organism:Homo sapiens (Human)
Description:Amino acid residues 1-309 were expressed as His-tagged fusion protein using baculovirus expression system.
Residue:309
Sequence:
MSSPRAVVQLGKAQPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLA
RLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLIL
EYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEV
KIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFE
SASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRV
LPPCAQMAS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50327912
NameBDBM50327912
Synonyms:3-(4-Morpholin-4-yl-benzoylamino)-1H-thieno[3,2-c]pyrazole-5-carboxylic acid((S)-1-phenyl-2-pyrrolidin-1-yl-ethyl)-amide | CHEMBL1258913
TypeSmall organic molecule
Emp. Form.C29H32N6O3S
Mol. Mass.544.668
SMILESO=C(N[C@H](CN1CCCC1)c1ccccc1)c1cc2n[nH]c(NC(=O)c3ccc(cc3)N3CCOCC3)c2s1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a