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TargetBeta-3 adrenergic receptor
LigandBDBM50328300
Substrate/Competitorn/a
Meas. Tech.ChEMBL_665493
EC50 0.040000±n/a nM
Citation Tasler, SBaumgartner, RAmmendola, ASchachtner, JWieber, TBlisse, MRath, SZaja, MKlahn, PQuotschalla, UNey, P Thienopyrimidines asß3-adrenoceptor agonists: hit-to-lead optimization. Bioorg Med Chem Lett20:6108-15 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Beta-3 adrenergic receptor
Name:Beta-3 adrenergic receptor
Synonyms:ADRB3 | B3AR | Beta-3 adrenoceptor | Beta-3 adrenoreceptor | adrenergic Beta3
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:43534.88
Organism:Homo sapiens (human)
Description:n/a
Residue:408
Sequence:
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIV
AIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLC
VTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRV
GADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRG
ELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGT
FTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLL
CRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50328300
n/a
NameBDBM50328300
Synonyms:4-(2-hydroxy-3-(1-(5-phenylthieno[2,3-d]pyrimidin-4-yl)piperidin-4-ylamino)propoxy)-2-(methoxymethyl)phenol | CHEMBL1257675
TypeSmall organic molecule
Emp. Form.C28H32N4O4S
Mol. Mass.520.643
SMILESCOCc1cc(OCC(O)CNC2CCN(CC2)c2ncnc3scc(-c4ccccc4)c23)ccc1O
Structure
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