Reaction Details Report a problem with these data
Target
Sterol O-acyltransferase 1
Ligand
BDBM50328357
Substrate
n/a
Meas. Tech.
ChEMBL_665508 (CHEMBL1261339)
IC50
1290±n/a nM
Citation
 Fox, BM; Iio, K; Li, K; Choi, R; Inaba, T; Jackson, S; Sagawa, S; Shan, B; Tanaka, M; Yoshida, A; Kayser, F Discovery of pyrrolopyridazines as novel DGAT1 inhibitors. Bioorg Med Chem Lett 20:6030-3 (2010) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACACT | ACACT1 | ACAT | ACAT1 | Acetyl-CoA acetyltransferase, mitochondrial | Acyl coenzyme A:cholesterol acyltransferase 1 | Acyl-CoA: cholesterol acyltransferase (ACAT) | Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) | Cholesterol acyltransferase 1 | SOAT | SOAT1 | SOAT1_HUMAN | STAT
Type:
Multi-pass membrane protein may form homo- or heterodimers.
Mol. Mass.:
64751.94
Organism:
Homo sapiens (Human)
Description:
P35610
Residue:
550
Sequence:
MVGEEKMSLRNRLSKSRENPEEDEDQRNPAKESLETPSNGRIDIKQLIAKKIKLTAEAEELKPFFMKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSVLEGEKNNHRAKDLRAPPEQGKIFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGKFPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHPLIRSLFHGFLFMIFQIGVLGFGPTYVVLAYTLPPASRFIIIFEQIRFVMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFVLFMFFGMAFNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYARQHCPLKNPTFLDYVRPRSWTCRYVF
  
Inhibitor
Name:
BDBM50328357
Synonyms:
CHEMBL1258828 | diethyl 7-(4-hydroxyphenyl)-2-morpholino-4-phenylpyrrolo[1,2-b]pyridazine-5,6-dicarboxylate
Type:
Small organic molecule
Emp. Form.:
C29H29N3O6
Mol. Mass.:
515.5571
SMILES:
CCOC(=O)c1c(C(=O)OCC)c2c(cc(nn2c1-c1ccc(O)cc1)N1CCOCC1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: