Target
Diacylglycerol O-acyltransferase 1
Ligand
BDBM50328366
Substrate
n/a
Meas. Tech.
ChEMBL_665507 (CHEMBL1261338)
IC50
120±n/a nM
Citation
 Fox, BMIio, KLi, KChoi, RInaba, TJackson, SSagawa, SShan, BTanaka, MYoshida, AKayser, F Discovery of pyrrolopyridazines as novel DGAT1 inhibitors. Bioorg Med Chem Lett 20:6030-3 (2010) [PubMed]  Article 
Target
Name:
Diacylglycerol O-acyltransferase 1
Synonyms:
ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase
Type:
Protein
Mol. Mass.:
55297.82
Organism:
Homo sapiens (Human)
Description:
O75907
Residue:
488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVGSGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVSVPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLNYEAPAAEA
  
Inhibitor
Name:
BDBM50328366
Synonyms:
CHEMBL1257328 | diethyl 4-phenyl-7-propyl-2-(pyrrolidin-1-yl)pyrrolo[1,2-b]pyridazine-5,6-dicarboxylate
Type:
Small organic molecule
Emp. Form.:
C26H31N3O4
Mol. Mass.:
449.542
SMILES:
CCCc1c(C(=O)OCC)c(C(=O)OCC)c2c(cc(nn12)N1CCCC1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: