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Target
Sterol O-acyltransferase 1
Ligand
BDBM50328391
Substrate
n/a
Meas. Tech.
ChEMBL_665508 (CHEMBL1261339)
IC50
500±n/a nM
Citation
 Fox, BM; Iio, K; Li, K; Choi, R; Inaba, T; Jackson, S; Sagawa, S; Shan, B; Tanaka, M; Yoshida, A; Kayser, F Discovery of pyrrolopyridazines as novel DGAT1 inhibitors. Bioorg Med Chem Lett 20:6030-3 (2010) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACACT | ACACT1 | ACAT | ACAT1 | Acetyl-CoA acetyltransferase, mitochondrial | Acyl coenzyme A:cholesterol acyltransferase 1 | Acyl-CoA: cholesterol acyltransferase (ACAT) | Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) | Cholesterol acyltransferase 1 | SOAT | SOAT1 | SOAT1_HUMAN | STAT
Type:
Multi-pass membrane protein may form homo- or heterodimers.
Mol. Mass.:
64751.94
Organism:
Homo sapiens (Human)
Description:
P35610
Residue:
550
Sequence:
MVGEEKMSLRNRLSKSRENPEEDEDQRNPAKESLETPSNGRIDIKQLIAKKIKLTAEAEELKPFFMKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSVLEGEKNNHRAKDLRAPPEQGKIFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGKFPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHPLIRSLFHGFLFMIFQIGVLGFGPTYVVLAYTLPPASRFIIIFEQIRFVMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFVLFMFFGMAFNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYARQHCPLKNPTFLDYVRPRSWTCRYVF
  
Inhibitor
Name:
BDBM50328391
Synonyms:
CHEMBL1257443 | diethyl 2-morpholino-4-phenyl-7-propylpyrrolo[1,2-f][1,2,4]triazine-5,6-dicarboxylate
Type:
Small organic molecule
Emp. Form.:
C25H30N4O5
Mol. Mass.:
466.5295
SMILES:
CCCc1c(C(=O)OCC)c(C(=O)OCC)c2c(nc(nn12)N1CCOCC1)-c1ccccc1
Structure:
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