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Target
Aurora kinase C
Ligand
BDBM50328436
Substrate
n/a
Meas. Tech.
ChEMBL_665542 (CHEMBL1261373)
IC50
1950±n/a nM
Citation
 Bouloc, N; Large, JM; Kosmopoulou, M; Sun, C; Faisal, A; Matteucci, M; Reynisson, J; Brown, N; Atrash, B; Blagg, J; McDonald, E; Linardopoulos, S; Bayliss, R; Bavetsias, V Structure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells. Bioorg Med Chem Lett 20:5988-93 (2010) [PubMed]  Article 
Target
Name:
Aurora kinase C
Synonyms:
AIE2 | AIK3 | AIRK3 | ARK3 | AURKC | AURKC_HUMAN | Aurora Kinase C (Aurora-C) | Aurora kinase C | Aurora kinase C (AURKC) | Aurora-C | Aurora-C/INCENP | Aurora/Ipl1-related kinase 3 | Aurora/Ipl1/Eg2 protein 2 | STK13 | Serine/threonine-protein kinase 13 | Serine/threonine-protein kinase Aurora-C
Type:
Enzyme
Mol. Mass.:
35602.43
Organism:
Homo sapiens (Human)
Description:
Amino acid residues 1-309 were expressed as His-tagged fusion protein using baculovirus expression system.
Residue:
309
Sequence:
MSSPRAVVQLGKAQPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRVLPPCAQMAS
  
Inhibitor
Name:
BDBM50328436
Synonyms:
3-chloro-N-(4-morpholin-4-ylphenyl)-6-pyridin-3-ylimidazo[1,2-a]pyrazin-8-amine | 3-chloro-N-(4-morpholinophenyl)-6-(pyridin-3-yl)imidazo[1,2-a]pyrazin-8-amine | CHEMBL1231066
Type:
Small organic molecule
Emp. Form.:
C21H19ClN6O
Mol. Mass.:
406.868
SMILES:
Clc1cnc2c(Nc3ccc(cc3)N3CCOCC3)nc(cn12)-c1cccnc1
Structure:
Search PDB for entries with ligand similarity: