Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 6
Ligand
BDBM50328462
Substrate
n/a
Meas. Tech.
ChEMBL_665589 (CHEMBL1261473)
Ki
447±n/a nM
Citation
 Vázquez-Villa, H; González-Vera, JA; Benhamú, B; Viso, A; Fernández de la Pradilla, R; Junquera, E; Aicart, E; López-Rodríguez, ML; Ortega-Gutiérrez, S Development of molecular probes for the human 5-HT(6) receptor. J Med Chem 53:7095-106 (2010) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46968.43
Organism:
Homo sapiens (Human)
Description:
P50406
Residue:
440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
  
Inhibitor
Name:
BDBM50328462
Synonyms:
5-Chloro-N-(3-{4-[8-({[5-(dimethylamino)-1-naphthyl]sulfonyl}-amino)octyl]piperazin-1-yl}-4-methoxyphenyl)-3-methyl-1-benzothiophene-2-sulfonamide | CHEMBL1256251
Type:
Small organic molecule
Emp. Form.:
C40H50ClN5O5S3
Mol. Mass.:
812.504
SMILES:
COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(CCCCCCCCNS(=O)(=O)c2cccc3c(cccc23)N(C)C)CC1
Structure:
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