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Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50328654
Substrate
n/a
Meas. Tech.
ChEMBL_665764 (CHEMBL1259255)
EC50
8.6±n/a nM
Citation
 Bollinger, S; Hübner, H; Heinemann, FW; Meyer, K; Gmeiner, P Novel pyridylmethylamines as highly selective 5-HT(1A) superagonists. J Med Chem 53:7167-79 (2010) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A
Type:
n/a
Mol. Mass.:
46122.49
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
422
Sequence:
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
  
Inhibitor
Name:
BDBM50328654
Synonyms:
(3-chloro-4-fluorophenyl)(4-fluoro-4-((methyl((5-methylpyridin-2-yl)methyl)amino)methyl)piperidin-1-yl)methanone | CHEMBL1259124
Type:
Small organic molecule
Emp. Form.:
C21H24ClF2N3O
Mol. Mass.:
407.885
SMILES:
CN(Cc1ccc(C)cn1)CC1(F)CCN(CC1)C(=O)c1ccc(F)c(Cl)c1
Structure:
Search PDB for entries with ligand similarity: