Reaction Details Report a problem with these data
Target
Lysosomal acid glucosylceramidase
Ligand
BDBM50329783
Substrate
n/a
Meas. Tech.
ChEMBL_674763 (CHEMBL1274071)
Ki
29000±n/a nM
Citation
 Aguilar-Moncayo, M; García-Moreno, MI; Stütz, AE; García Fernández, JM; Wrodnigg, TM; Ortiz Mellet, C Fluorescent-tagged sp2-iminosugars with potentß-glucosidase inhibitory activity. Bioorg Med Chem 18:7439-45 (2010) [PubMed]  Article 
Target
Name:
Lysosomal acid glucosylceramidase
Synonyms:
Acid beta-glucosidase | D-glucosyl-N-acylsphingosine glucohydrolase | GBA | GBA1 | GBA1_BOVIN | Glucosylceramidase
Type:
PROTEIN
Mol. Mass.:
59862.93
Organism:
Bos taurus
Description:
ChEMBL_1460504
Residue:
536
Sequence:
MELSSPSREEYPMPRGRVGIMAASLMGLLLLHTVSWVSGARPCSPKSFGYSSVVCVCNGTYCDSLDPLTLPDPGTFSRFESTRSGRRMELSLGTIQANRTGTGLLLTLQPDQKFQKVKGFGGAMTDAAALNILALSPAARNLLLKSYFSEEGIEYNIIRVPMASCDFSIRTYTYDDSPDDFQLLNFSLPEEDVKLKIPLIHQALELANRSVSLFASPWTSPTWLKTNGAVNGKGTLKGQAGDLYHKTWARYFVKFLDAYAEHKLRFWAVTAENEPTAGLLTGYPFQCLGFTPEHQRDFIARDLGPILANSTHRDVRLLMLDDQRLLLPRWAQVVLADPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMRYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDIAKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASKKSDLDTVALLRPDGSAVAVVLNRSSKDVPLTIKDPAVGFMETVSPGYSIHTYLWRRQ
  
Inhibitor
Name:
BDBM50329783
Synonyms:
5-N,6-S-[N'-(4-Dansylamino)butyliminomethylidene]-6-thionojirimycin | CHEMBL1272018
Type:
Small organic molecule
Emp. Form.:
C23H32N4O6S2
Mol. Mass.:
524.653
SMILES:
CN(C)c1cccc2c(cccc12)S(=O)(=O)NCCCC\N=C1/SC[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O)N12 |r|
Structure:
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