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Target
Cathepsin B
Ligand
BDBM50330031
Substrate
n/a
Meas. Tech.
ChEMBL_676070 (CHEMBL1273064)
IC50
1600±n/a nM
Citation
 Kumar, GD; Chavarria, GE; Charlton-Sevcik, AK; Yoo, GK; Song, J; Strecker, TE; Siim, BG; Chaplin, DJ; Trawick, ML; Pinney, KG Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L. Bioorg Med Chem Lett 20:6610-5 (2010) [PubMed]  Article 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM50330031
Synonyms:
CHEMBL1272261 | [(3-Bromophenyl)-(3-acetoxyphenyl)-ketone]thiosemicarbazone
Type:
Small organic molecule
Emp. Form.:
C16H14BrN3O2S
Mol. Mass.:
392.27
SMILES:
CC(=O)Oc1cccc(c1)C(=NNC(N)=S)c1cccc(Br)c1 |w:11.12|
Structure:
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