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TargetDNA Gyrase Subunit B
LigandBDBM50330309
Substrate/Competitorn/a
Meas. Tech.ChEMBL_677264
IC50 22±n/a nM
Citation Anderle, CStieger, MBurrell, MReinelt, SMaxwell, APage, MHeide, L Biological activities of novel gyrase inhibitors of the aminocoumarin class. Antimicrob Agents Chemother52:1982-90 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
DNA Gyrase Subunit B
Name:DNA Gyrase Subunit B
Synonyms:DNA gyrase subunit B (gyrB) | Type IIA topoisomerase subunit GyrB | gyrb
Type:Enzyme Subunit
Mol. Mass.:89941.28
Organism:Escherichia coli (strain K12)
Description:P0AES6
Residue:804
Sequence:
MSNSYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCKEII
VTIHADNSVSVQDDGRGIPTGIHPEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGV
SVVNALSQKLELVIQREGKIHRQIYEHGVPQAPLAVTGETEKTGTMVRFWPSLETFTNVT
EFEYEILAKRLRELSFLNSGVSIRLRDKRDGKEDHFHYEGGIKAFVEYLNKNKTPIHPNI
FYFSTEKDGIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHLAGFRAAMTRTLNAYMDKE
GYSKKAKVSATGDDAREGLIAVVSVKVPDPKFSSQTKDKLVSSEVKSAVEQQMNELLAEY
LLENPTDAKIVVGKIIDAARAREAARRAREMTRRKGALDLAGLPGKLADCQERDPALSEL
YLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIGR
DEYNPDKLRYHSIIIMTDADVDGSHIRTLLLTFFYRQMPEIVERGHVYIAQPPLYKVKKG
KQEQYIKDDEAMDQYQISIALDGATLHTNASAPALAGEALEKLVSEYNATQKMINRMERR
YPKAMLKELIYQPTLTEADLSDEQTVTRWVNALVSELNDKEQHGSQWKFDVHTNAEQNLF
EPIVRVRTHGVDTDYPLDHEFITGGEYRRICTLGEKLRGLLEEDAFIERGERRQPVASFE
QALDWLVKESRRGLSIQRYKGLGEMNPEQLWETTMDPESRRMLRVTVKDAIAADQLFTTL
MGDAVEPRRAFIEENALKAANIDI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50330309
NameBDBM50330309
Synonyms:(3R,4S,5R,6S)-6-(8-chloro-4-hydroxy-3-(4-hydroxy-3-methoxybenzamido)-2-oxo-2H-chromen-7-yloxy)-5-hydroxy-3-methoxy-2,2-dimethyltetrahydro-2H-pyran-4-yl 5-methyl-1H-pyrrole-2-carboxylate | CHEMBL1275884
TypeSmall organic molecule
Emp. Form.C31H31ClN2O12
Mol. Mass.659.037
SMILESCO[C@@H]1[C@@H](OC(=O)c2ccc(C)[nH]2)[C@@H](O)[C@H](Oc2ccc3c(O)c(NC(=O)c4ccc(O)c(OC)c4)c(=O)oc3c2Cl)OC1(C)C |r|
Structure
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