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Target
Inositol phosphorylceramide synthase
Ligand
BDBM50333123
Substrate
n/a
Meas. Tech.
ChEMBL_690931 (CHEMBL1634539)
Ki
10500±n/a nM
Citation
 Aeed, PA; Young, CL; Nagiec, MM; Elhammer, AP Inhibition of inositol phosphorylceramide synthase by the cyclic peptide aureobasidin A. Antimicrob Agents Chemother 53:496-504 (2009) [PubMed]  Article 
Target
Name:
Inositol phosphorylceramide synthase
Synonyms:
AUR1 | AUR1_CANAL | Aureobasidin A resistance protein homolog | IPC synthase | Phosphatidylinositol:ceramide phosphoinositol transferase
Type:
PROTEIN
Mol. Mass.:
53452.25
Organism:
Candida albicans
Description:
ChEMBL_690931
Residue:
471
Sequence:
MASSILRSKIIQKPYQLFHYYFLSEKAPGSTVSDLNFDTNIQTSLRKLKHHHWTVGEIFHYGFLVSILFFVFVVFPASFFIKLPIILAFATCFLIPLTSQFFLPALPVFTWLALYFTCAKIPQEWKPAITVKVLPAMETILYGDNLSNVLATITTGVLDILAWLPYGIIHFSFPFVLAAIIFLFGPPTALRSFGFAFGYMNLLGVLIQMAFPAAPPWYKNLHGLEPANYSMHGSPGGLGRIDKLLGVDMYTTGFSNSSIIFGAFPSLHSGCCIMEVLFLCWLFPRFKFVWVTYASWLWWSTMYLTHHYFVDLIGGAMLSLTVFEFTKYKYLPKNKEGLFCRWSYTEIEKIDIQEIDPLSYNYIPINSNDNESRLYTRVYQESQVSPPSRAETPEAFEMSNFSRSRQSSKTQVPLSNLTNNDQVPGINEEDEEEEGDEISSSTPSVFEDEPQGSTYAASSATSVDDLDSKRN
  
Inhibitor
Name:
BDBM50333123
Synonyms:
(R)-2-((3,4-dimethoxyphenethyl)(methyl)amino)-2-oxo-1-phenylethyl 3-hydroxy-3-methyl-2-(N-methyl-6-phenylhexanamido)butanoate | CHEMBL1631584
Type:
Small organic molecule
Emp. Form.:
C37H48N2O7
Mol. Mass.:
632.7862
SMILES:
COc1ccc(CCN(C)C(=O)[C@H](OC(=O)C(N(C)C(=O)CCCCCc2ccccc2)C(C)(C)O)c2ccccc2)cc1OC |r|
Structure:
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