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TargetGABA transporter 1
LigandBDBM50417660
Substrate/Competitorn/a
Meas. Tech.ChEMBL_699418
Ki 93.33±n/a nM
Citation Pizzi, DALeslie, CPDi Fabio, RSeri, CBernasconi, GSquaglia, MCarnevale, GFalchi, AGreco, EMangiarini, LNegri, M Stereospecific synthesis and structure-activity relationships of unsymmetrical 4,4-diphenylbut-3-enyl derivatives of nipecotic acid as GAT-1 inhibitors. Bioorg Med Chem Lett21:602-5 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
GABA transporter 1
Name:GABA transporter 1
Synonyms:GAT-1 | Sodium- and chloride-dependent GABA transporter 1 | Solute carrier family 6 member 1
Type:PROTEIN
Mol. Mass.:67079.40
Organism:Homo sapiens (Human)
Description:ChEMBL_1454196
Residue:599
Sequence:
MATNGSKVADGQISTEVSEAPVANDKPKTLVVKVQKKAADLPDRDTWKGRFDFLMSCVGY
AIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAP
MFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSMV
NTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWILVYFCIWKGVGWTGKVV
YFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGL
GSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASG
PGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRR
ELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRF
YDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPLTMGNYVFPKWGQGVGWLM
ALSSMVLIPGYMAYMFLTLKGSLKQRIQVMVQPSEDIVRPENGPEQPQAGSSTSKEAYI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50417660
NameBDBM50417660
Synonyms:CHEMBL1642377
TypeSmall organic molecule
Emp. Form.C23H24F3NO2
Mol. Mass.403.4374
SMILESOC(=O)[C@@H]1CCCN(CC\C=C(\c2ccccc2)c2ccccc2C(F)(F)F)C1 |r|
Structure
n/a