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Target
Beta-carbonic anhydrase 1
Ligand
BDBM50334360
Substrate
n/a
Meas. Tech.
ChEMBL_700107 (CHEMBL1646989)
Ki
470±n/a nM
Citation
 Pacchiano, F; Carta, F; Vullo, D; Scozzafava, A; Supuran, CT Inhibition ofß-carbonic anhydrases with ureido-substituted benzenesulfonamides. Bioorg Med Chem Lett 21:102-5 (2010) [PubMed]  Article 
Target
Name:
Beta-carbonic anhydrase 1
Synonyms:
β-Carbonic anhydrase 1 (CA 1) | Carbonic Anhydrase (mtCA 1) | MTCA1_MYCTU | Uncharacterized protein Rv1284/MT1322 | canA | mtcA1
Type:
Enzyme
Mol. Mass.:
18186.06
Organism:
Mycobacterium tuberculosis
Description:
The recombinant GST-mtCA1 construct was cloned, expressed, and further purified from E. coli. The purified protein was used in inhibition assays.
Residue:
163
Sequence:
MTVTDDYLANNVDYASGFKGPLPMPPSKHIAIVACMDARLDVYRMLGIKEGEAHVIRNAGCVVTDDVIRSLAISQRLLGTREIILLHHTDCGMLTFTDDDFKRAIQDETGIRPTWSPESYPDAVEDVRQSLRRIEVNPFVTKHTSLRGFVFDVATGKLNEVTP
  
Inhibitor
Name:
BDBM50334360
Synonyms:
4-(3-(4-acetylphenyl)ureido)benzenesulfonamide | 4-{([(4'-Acetylphenyl)amino]carbonyl)amino}benzenesulfonamide | CA IX inhibitor, (C)2 | CHEMBL1643295
Type:
Small organic molecule
Emp. Form.:
C15H15N3O4S
Mol. Mass.:
333.362
SMILES:
CC(=O)c1ccc(NC(=O)Nc2ccc(cc2)S(N)(=O)=O)cc1
Structure:
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