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Target
5-hydroxytryptamine receptor 7
Ligand
BDBM50334523
Substrate
n/a
Meas. Tech.
ChEMBL_701285 (CHEMBL1648905)
Ki
450±n/a nM
Citation
 Rudolph, DA; Dvorak, CA; Dvorak, L; Nepomuceno, D; Bonaventure, P; Lovenberg, TW; Carruthers, NI Novel tetrahydropyrido[3,2-c]pyrroles as 5-HT(7) antagonists. Bioorg Med Chem Lett 21:42-4 (2010) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 7
Synonyms:
5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-Hydroxytryptamine receptor 7 (5-HT7) | 5-hydroxytryptamine receptor 7 | 5-hydroxytryptamine receptor 7 (5-HT-7) | 5HT7R_RAT | Adrenergic Alpha | GPRFO | Htr7 | Serotonin (5-HT) receptor | Serotonin Receptor 7
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
49852.62
Organism:
Rattus norvegicus (rat)
Description:
Rat cloned 5-HT7R.
Residue:
448
Sequence:
MMDVNSSGRPDLYGHLRSLILPEVGRGLQDLSPDGGAHPVVSSWMPHLLSGFLEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFVLQNSDHCGKKGHDT
  
Inhibitor
Name:
BDBM50334523
Synonyms:
1-benzyl-3-(4-nitrophenyl)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine | CHEMBL1644274
Type:
Small organic molecule
Emp. Form.:
C20H19N3O2
Mol. Mass.:
333.3838
SMILES:
[O-][N+](=O)c1ccc(cc1)-c1cn(Cc2ccccc2)c2CCNCc12
Structure:
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