Target
5-hydroxytryptamine receptor 2B
Ligand
BDBM50335604
Substrate
n/a
Meas. Tech.
ChEMBL_714921 (CHEMBL1663916)
Ki
1541±n/a nM
Citation
 Lin, ZAntemano, RRHughen, RWTianero, MDPeraud, OHaygood, MGConcepcion, GPOlivera, BMLight, ASchmidt, EW Pulicatins A-E, neuroactive thiazoline metabolites from cone snail-associated bacteria. J Nat Prod 73:1922-6 (2010) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2B
Synonyms:
5-HT-2B | 5-HT2B | 5-hydroxytryptamine (serotonin) receptor 2B [Homo sapiens] | 5-hydroxytryptamine receptor 2B (5-HT2B) | 5-hydroxytryptamine receptor 2C (5HT2C) | 5HT2B_HUMAN | HTR2B | Serotonin (5-HT3) receptor | Serotonin 2b (5-HT2b) receptor | Serotonin Receptor 2B
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
54312.47
Organism:
Homo sapiens (Human)
Description:
Receptor binding assays were performed using human clone stably expressed in CHO cells.
Residue:
481
Sequence:
MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV
  
Inhibitor
Name:
BDBM50335604
Synonyms:
CHEMBL1651096 | pulicatin D
Type:
Small organic molecule
Emp. Form.:
C11H9NO2S
Mol. Mass.:
219.26
SMILES:
Cc1sc(nc1C=O)-c1ccccc1O
Structure:
Search PDB for entries with ligand similarity: