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Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM50336001
Substrate
n/a
Meas. Tech.
ChEMBL_717059 (CHEMBL1671177)
Ki
0.87±n/a nM
Citation
 Burch, JD; Farand, J; Colucci, J; Sturino, C; Ducharme, Y; Friesen, RW; Lévesque, JF; Gagné, S; Wrona, M; Therien, AG; Mathieu, MC; Denis, D; Vigneault, E; Xu, D; Clark, P; Rowland, S; Han, Y Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP4 receptor. Bioorg Med Chem Lett 21:1041-6 (2011) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor
Type:
Enzyme
Mol. Mass.:
53134.53
Organism:
Homo sapiens (Human)
Description:
P35408
Residue:
488
Sequence:
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
  
Inhibitor
Name:
BDBM50336001
Synonyms:
CHEMBL1669020 | N-(4-(5,9-diethoxy-6-oxo-6H-pyrrolo[3,4-g]quinolin-7(8H)-yl)-3-methylphenethyl)-2-(2-methoxyphenyl)acetamide
Type:
Small organic molecule
Emp. Form.:
C33H35N3O5
Mol. Mass.:
553.6481
SMILES:
CCOc1c2C(=O)N(Cc2c(OCC)c2ncccc12)c1ccc(CCNC(=O)Cc2ccccc2OC)cc1C
Structure:
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