Reaction Details Report a problem with these data
Target
Polyphenol oxidase 2
Ligand
BDBM50336368
Substrate
n/a
Meas. Tech.
ChEMBL_716753 (CHEMBL1670635)
IC50
6230±n/a nM
Citation
 Fang, Y; Chen, Y; Feng, G; Ma, L Benzyl benzoates: New phlorizin analogs as mushroom tyrosinase inhibitors. Bioorg Med Chem 19:1167-71 (2011) [PubMed]  Article 
Target
Name:
Polyphenol oxidase 2
Synonyms:
Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase
Type:
Protein
Mol. Mass.:
63923.66
Organism:
Agaricus bisporus (Common mushroom)
Description:
O42713
Residue:
556
Sequence:
MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLPFTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWVQAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPYGDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDDQHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVWVTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGGTKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKKFELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNHYLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDHTQARVVFDDVAVHVIN
  
Inhibitor
Name:
BDBM50336368
Synonyms:
3-Hydroxybenzyl 2,4-dihydroxybenzoate | CHEMBL1668056
Type:
Small organic molecule
Emp. Form.:
C14H12O5
Mol. Mass.:
260.2421
SMILES:
Oc1cccc(COC(=O)c2ccc(O)cc2O)c1
Structure:
Search PDB for entries with ligand similarity: