Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM50336507
Substrate
n/a
Meas. Tech.
ChEMBL_725476 (CHEMBL1677337)
Ki
1±n/a nM
Citation
 Wang, F; Jain, P; Gulten, G; Liu, Z; Feng, Y; Ganesula, K; Motiwala, AS; Ioerger, TR; Alland, D; Vilchèze, C; Jacobs, WR; Sacchettini, JC Mycobacterium tuberculosis dihydrofolate reductase is not a target relevant to the antitubercular activity of isoniazid. Antimicrob Agents Chemother 54:3776-82 (2010) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_MYCTU | dfrA | folA
Type:
PROTEIN
Mol. Mass.:
17872.62
Organism:
Mycobacterium tuberculosis
Description:
ChEMBL_102873
Residue:
161
Sequence:
MTMVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNVVLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIGLPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHRS
  
Inhibitor
Name:
BDBM50336507
Synonyms:
4-pyridinecarbohydrazide(Isoniazid) | CHEMBL64 | Dow-isoniazid | Hyzyd | INH | ISONICOTINIC ACID HYDRAZIDE(ISONIAZIDE) | Isoniazid (INH) | Isonicotinic acid hydrazide (Isoniazid) | Isonicotinic acid hydrazide(Isoniazid) | Isonicotinylhydrazine | Laniazid | Nydrazid | Rimifon | Stanozide | isoniazid | isonicotinamide | isonicotinhydrazide | isonicotinohydrazide | isonicotinyl hydrazide | pyridine-4-carbohydrazide
Type:
Small organic molecule
Emp. Form.:
C6H7N3O
Mol. Mass.:
137.1393
SMILES:
NNC(=O)c1ccncc1
Structure:
Search PDB for entries with ligand similarity: