Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM50336602
Substrate
n/a
Meas. Tech.
ChEMBL_725830 (CHEMBL1678426)
Ki
16±n/a nM
Citation
 Cheng, K; Lee, YS; Rothman, RB; Dersch, CM; Bittman, RW; Jacobson, AE; Rice, KC Probes for narcotic receptor mediated phenomena. 41. Unusual inverseµ-agonists and potentµ-opioid antagonists by modification of the N-substituent in enantiomeric 5-(3-hydroxyphenyl)morphans. J Med Chem 54:957-69 (2011) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50336602
Synonyms:
3-((1S,5R)-2-(((1'S,2'S)-2-Phenylcyclopropyl)methyl)-2-azabicyclo[3.3.1]nonan-5-yl)phenol hydrochloride | CHEMBL1672183
Type:
Small organic molecule
Emp. Form.:
C24H29NO
Mol. Mass.:
347.4932
SMILES:
Oc1cccc(c1)[C@]12CCC[C@H](C1)N(C[C@H]1C[C@@H]1c1ccccc1)CC2 |r|
Structure:
Search PDB for entries with ligand similarity: