Reaction Details Report a problem with these data
Target
Cholesteryl ester transfer protein
Ligand
BDBM50337153
Substrate
n/a
Meas. Tech.
ChEMBL_726319 (CHEMBL1687307)
IC50
13±n/a nM
Citation
 Sweis, RF; Hunt, JA; Kallashi, F; Hammond, ML; Chen, Y; Eveland, SS; Guo, Q; Hyland, SA; Milot, DP; Cumiskey, AM; Latham, M; Rosa, R; Peterson, L; Sparrow, CP; Wright, SD; Anderson, MS; Sinclair, PJ 2-(4-carbonylphenyl)benzoxazole inhibitors of CETP: scaffold design and advancement in HDLc-raising efficacy. Bioorg Med Chem Lett 21:1890-5 (2011) [PubMed]  Article 
Target
Name:
Cholesteryl ester transfer protein
Synonyms:
CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I
Type:
Enzyme
Mol. Mass.:
54751.53
Organism:
Homo sapiens (Human)
Description:
P11597
Residue:
493
Sequence:
MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDITGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVITASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRLMLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSSVMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSESVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS
  
Inhibitor
Name:
BDBM50337153
Synonyms:
4-(5-cyano-7-isopropylbenzo[d]oxazol-2-yl)-N-((1-(5-(5-fluoro-2-isopropoxyphenyl)pyridin-2-yl)piperidin-4-yl)methyl)benzamide | CHEMBL1682748
Type:
Small organic molecule
Emp. Form.:
C38H38FN5O3
Mol. Mass.:
631.7384
SMILES:
CC(C)Oc1ccc(F)cc1-c1ccc(nc1)N1CCC(CNC(=O)c2ccc(cc2)-c2nc3cc(cc(C(C)C)c3o2)C#N)CC1
Structure:
Search PDB for entries with ligand similarity: