Reaction Details Report a problem with these data
Target
Sphingosine 1-phosphate receptor 3
Ligand
BDBM50337596
Substrate
n/a
Meas. Tech.
ChEMBL_728640 (CHEMBL1685770)
EC50
>10000±n/a nM
Citation
 Kurata, H; Otsuki, K; Kusumi, K; Kurono, M; Terakado, M; Seko, T; Mizuno, H; Ono, T; Hagiya, H; Minami, M; Nakade, S; Habashita, H Structure-activity relationship studies of sphingosine-1-phosphate receptor agonists with N-cinnamyl-ß-alanine moiety. Bioorg Med Chem Lett 21:1390-3 (2011) [PubMed]  Article 
Target
Name:
Sphingosine 1-phosphate receptor 3
Synonyms:
C9orf108 | C9orf47 | EDG3 | Endothelial differentiation G-protein coupled receptor 3 | S1P receptor 3 | S1P receptor Edg-3 | S1P3 | S1PR3 | S1PR3_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor 3 (S1P3) | Sphingosine 1-phosphate receptor Edg-3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42278.13
Organism:
Homo sapiens (Human)
Description:
Q99500
Residue:
378
Sequence:
MATALPPRLQPVRGNETLREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMVLIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSMFVALGASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLHNLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSSSRKVANHNNSERSMALLRTVVIVVSVFIACWSPLFILFLIDVACRVQACPILFKAQWFIVLAVLNSAMNPVIYTLASKEMRRAFFRLVCNCLVRGRGARASPIQPALDPSRSKSSSSNNSSHSPKVKEDLPHTAPSSCIMDKNAALQNGIFCN
  
Inhibitor
Name:
BDBM50337596
Synonyms:
CHEMBL1683048 | cis-3-(3-(4-(3-phenylpropoxy)phenyl)but-2-enylamino)propanoic acid
Type:
Small organic molecule
Emp. Form.:
C22H27NO3
Mol. Mass.:
353.4547
SMILES:
C\C(=C\CNCCC(O)=O)c1ccc(OCCCc2ccccc2)cc1
Structure:
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