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Target
RAC-alpha serine/threonine-protein kinase
Ligand
BDBM50338962
Substrate
n/a
Meas. Tech.
ChEMBL_727296 (CHEMBL1687390)
Ki
40000±n/a nM
Citation
 Ahad, AM; Zuohe, S; Du-Cuny, L; Moses, SA; Zhou, LL; Zhang, S; Powis, G; Meuillet, EJ; Mash, EA Development of sulfonamide AKT PH domain inhibitors. Bioorg Med Chem 19:2046-54 (2011) [PubMed]  Article 
Target
Name:
RAC-alpha serine/threonine-protein kinase
Synonyms:
AKT1 kinase | AKT1_MOUSE | Akt | Akt1 | PKB | PKB alpha | Protein kinase B | Protein kinase B alpha | Proto-oncogene c-Akt | RAC-PK-alpha | Rac | Thymoma viral proto-oncogene
Type:
PROTEIN
Mol. Mass.:
55700.67
Organism:
Mus musculus
Description:
ChEMBL_727296
Residue:
480
Sequence:
MNDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQRESPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWATAIQTVADGLKRQEEETMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPTQRLGGGSEDAKEIMQHRFFANIVWQDVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
  
Inhibitor
Name:
BDBM50338962
Synonyms:
2-(5-(Biphen-4-ylsulfonamido)-1,3,4-thiadiazol-2-yl)acetate | CHEMBL1685061
Type:
Small organic molecule
Emp. Form.:
C15H13N3O3S2
Mol. Mass.:
347.412
SMILES:
OCc1nnc(NS(=O)(=O)c2ccc(cc2)-c2ccccc2)s1
Structure:
Search PDB for entries with ligand similarity: