Reaction Details Report a problem with these data
Target
Steroidogenic factor 1
Ligand
BDBM22373
Substrate
n/a
Meas. Tech.
ChEMBL_743680 (CHEMBL1767449)
EC50
158.49±n/a nM
Citation
Whitby, RJ; Stec, J; Blind, RD; Dixon, S; Leesnitzer, LM; Orband-Miller, LA; Williams, SP; Willson, TM; Xu, R; Zuercher, WJ; Cai, F; Ingraham, HA Small molecule agonists of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and liver receptor homologue-1 (LRH-1, NR5A2). J Med Chem 54:2266-81 (2011) [PubMed] Article
More Info.:
Target
Name:
Steroidogenic factor 1
Synonyms:
AD4BP | Adrenal 4-binding protein | FTZF1 | Fushi tarazu factor homolog 1 | NR5A1 | Nuclear receptor subfamily 5 group A member 1 | SF-1 | SF1 | STF-1 | STF1_HUMAN | Steroid hormone receptor Ad4BP
Type:
Nuclear Hormone Receptor
Mol. Mass.:
51643.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
461
Sequence:
MDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKTQRKRCPFCRFQKCLTVGMRLEAVRADRMRGGRNKFGPMYKRDRALKQQKKAQIRANGFKLETGPPMGVPPPPPPAPDYVLPPSLHGPEPKGLAAGPPAGPLGDFGAPALPMAVPGAHGPLAGYLYPAFPGRAIKSEYPEPYASPPQPGLPYGYPEPFSGGPNVPELILQLLQLEPDEDQVRARILGCLQEPTKSRPDQPAAFGLLCRMADQTFISIVDWARRCMVFKELEVADQMTLLQNCWSELLVFDHIYRQVQHGKEGSILLVTGQEVELTTVATQAGSLLHSLVLRAQELVLQLLALQLDRQEFVCLKFIILFSLDLKFLNNHILVKDAQEKANAALLDYTLCHYPHCGDKFQQLLLCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIEMLQAKQT
Inhibitor
Name:
BDBM22373
Synonyms:
(3aS,6aR)-5-[(4E)-oct-4-en-4-yl]-N,4-diphenyl-1,2,3,3a,6,6a-hexahydropentalen-3a-amine | GSK 8470 | bicyclo[3.3.0]-oct-2-ene, 5a
Type:
Small organic molecule
Emp. Form.:
C28H35N
Mol. Mass.:
385.5842
SMILES:
[H][C@]12CCC[C@@]1(Nc1ccccc1)C(=C(C2)C(\CCC)=C\CCC)c1ccccc1 |r,c:15|