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Target
TGF-beta receptor type-1
Ligand
BDBM50342220
Substrate
n/a
Meas. Tech.
ChEMBL_743052 (CHEMBL1768523)
IC50
75±n/a nM
Citation
 Jin, CH; Krishnaiah, M; Sreenu, D; Rao, KS; Subrahmanyam, VB; Park, CY; Son, JY; Sheen, YY; Kim, DK Synthesis and biological evaluation of 1-substituted-3(5)-(6-methylpyridin-2-yl)-4-(quinolin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors. Bioorg Med Chem 19:2633-40 (2011) [PubMed]  Article 
Target
Name:
TGF-beta receptor type-1
Synonyms:
ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I
Type:
enzyme
Mol. Mass.:
55968.24
Organism:
Homo sapiens (Human)
Description:
P36897
Residue:
503
Sequence:
MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
  
Inhibitor
Name:
BDBM50342220
Synonyms:
3-(2-(3-(6-Methylpyridin-2-yl)-4-(quinolin-6-yl)-1Hpyrazol-yl)-1H-pyrazol-acetamido)benzamide | CHEMBL1766444
Type:
Small organic molecule
Emp. Form.:
C27H22N6O2
Mol. Mass.:
462.5026
SMILES:
Cc1cccc(n1)-c1nn(CC(=O)Nc2cccc(c2)C(N)=O)cc1-c1ccc2ncccc2c1
Structure:
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