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Target
Acid-sensing ion channel 3
Ligand
BDBM50342663
Substrate
n/a
Meas. Tech.
ChEMBL_745055 (CHEMBL1772131)
IC50
27600±n/a nM
Citation
 Wolkenberg, SE; Zhao, Z; Mulhearn, JJ; Harrison, ST; Sanders, JM; Cato, MJ; Jovanovska, A; Panigel, J; Cook, SP; Henze, DA; Kane, SA; Hartman, GD; Barrow, JC High concentration electrophysiology-based fragment screen: discovery of novel acid-sensing ion channel 3 (ASIC3) inhibitors. Bioorg Med Chem Lett 21:2646-9 (2011) [PubMed]  Article 
Target
Name:
Acid-sensing ion channel 3
Synonyms:
ACCN3 | ASIC3 | ASIC3_HUMAN | Amiloride-sensitive cation channel 3 | SLNAC1 | TNAC1
Type:
PROTEIN
Mol. Mass.:
58910.26
Organism:
Homo sapiens (Human)
Description:
ChEMBL_757561
Residue:
531
Sequence:
MKPTSGPEEARRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTALDERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPAEHAAFLRALGRPPAPPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIFTRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAMLRKDSCACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQHSQRHSSTNLLQEGLGSHRTQVPHLSLGPRPPTPPCAVTKTLSASHRTCYLVTQL
  
Inhibitor
Name:
BDBM50342663
Synonyms:
4-(6-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-2-methylquinoline | CHEMBL1770742
Type:
Small organic molecule
Emp. Form.:
C19H17BrN2
Mol. Mass.:
353.256
SMILES:
Cc1cc(N2CCc3cc(Br)ccc3C2)c2ccccc2n1
Structure:
Search PDB for entries with ligand similarity: