Reaction Details Report a problem with these data
Target
Interstitial collagenase
Ligand
BDBM50343086
Substrate
n/a
Meas. Tech.
ChEMBL_744949 (CHEMBL1771908)
Ki
>10000±n/a nM
Citation
Barta, TE; Becker, DP; Bedell, LJ; Easton, AM; Hockerman, SL; Kiefer, J; Munie, GE; Mathis, KJ; Li, MH; Rico, JG; Villamil, CI; Williams, JM MMP-13 selectivea-sulfone hydroxamates: a survey of P1' heterocyclic amide isosteres. Bioorg Med Chem Lett 21:2820-2 (2011) [PubMed] Article
More Info.:
Target
Name:
Interstitial collagenase
Synonyms:
CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1)
Type:
Enzyme
Mol. Mass.:
54010.26
Organism:
Homo sapiens (Human)
Description:
P03956
Residue:
469
Sequence:
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
Inhibitor
Name:
BDBM50343086
Synonyms:
CHEMBL1771221 | N-hydroxy-4-(4-(3-(4-(4-(trifluoromethoxy)phenyl)-1H-imidazol-1-yl)propoxy)phenylsulfonyl)tetrahydro-2H-pyran-4-carboxamide
Type:
Small organic molecule
Emp. Form.:
C25H26F3N3O7S
Mol. Mass.:
569.55
SMILES:
ONC(=O)C1(CCOCC1)S(=O)(=O)c1ccc(OCCCn2cnc(c2)-c2ccc(OC(F)(F)F)cc2)cc1