Reaction Details Report a problem with these data
Target
Sphingosine 1-phosphate receptor 4
Ligand
BDBM50344799
Substrate
n/a
Meas. Tech.
ChEMBL_749238 (CHEMBL1781181)
IC50
25±n/a nM
Citation
 Guerrero, M; Urbano, M; Velaparthi, S; Zhao, J; Schaeffer, MT; Brown, S; Rosen, H; Roberts, E Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists. Bioorg Med Chem Lett 21:3632-6 (2011) [PubMed]  Article 
Target
Name:
Sphingosine 1-phosphate receptor 4
Synonyms:
EDG6 | Endothelial differentiation G-protein coupled receptor 6 | S1P receptor 4 | S1P receptor Edg-6 | S1P4 | S1PR4 | S1PR4_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-6 | Sphingosine-1-phosphate receptor 4 | sphingosine-1-phosphate 4 S1P4
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41647.39
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
384
Sequence:
MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDSFRGSRSLSFRMREPLSSISSVRSI
  
Inhibitor
Name:
BDBM50344799
Synonyms:
CHEMBL1779732 | N-(4-(aminomethyl)-2,6-dimethylphenyl)-5-(2,5-dichlorophenyl)furan-2-carboxamide
Type:
Small organic molecule
Emp. Form.:
C20H18Cl2N2O2
Mol. Mass.:
389.275
SMILES:
Cc1cc(CN)cc(C)c1NC(=O)c1ccc(o1)-c1cc(Cl)ccc1Cl
Structure:
Search PDB for entries with ligand similarity: