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Target
Programmed cell death protein 4
Ligand
BDBM50345543
Substrate
n/a
Meas. Tech.
ChEMBL_751484 (CHEMBL1787264)
EC50
1500±n/a nM
Citation
 Grkovic, T; Blees, JS; Colburn, NH; Schmid, T; Thomas, CL; Henrich, CJ; McMahon, JB; Gustafson, KR Cryptocaryols A-H,a-pyrone-containing 1,3-polyols from Cryptocarya sp. implicated in stabilizing the tumor suppressor Pdcd4. J Nat Prod 74:1015-20 (2011) [PubMed]  Article 
Target
Name:
Programmed cell death protein 4
Synonyms:
H731 | Neoplastic transformation inhibitor protein | Nuclear antigen H731-like | PDCD4 | PDCD4_HUMAN | Protein 197/15a
Type:
PROTEIN
Mol. Mass.:
51720.55
Organism:
Homo sapiens (Human)
Description:
ChEMBL_776474
Residue:
469
Sequence:
MDVENEQILNVNPADPDNLSDSLFSGDEENAGTEEIKNEINGNWISASSINEARINAKAKRRLRKNSSRDSGRGDSVSDSGSDALRSGLTVPTSPKGRLLDRRSRSGKGRGLPKKGGAGGKGVWGTPGQVYDVEEVDVKDPNYDDDQENCVYETVVLPLDERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVMSTTDVEKSFDKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQSVNHLVKEIDMLLKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNEIPDINLDVPHSYSVLERFVEECFQAGIISKQLRDLCPSRGRKRFVSEGDGGRLKPESY
  
Inhibitor
Name:
BDBM50345543
Synonyms:
CHEMBL1784375 | Cryptocaryol D
Type:
Small organic molecule
Emp. Form.:
C32H58O9
Mol. Mass.:
586.7975
SMILES:
CCCCCCCCCCCCCCC[C@H](C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@@H]1OC(=O)C=C[C@@H]1O)OC(C)=O |r,c:33|
Structure:
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