Reaction Details Report a problem with these data
Target
Sphingosine 1-phosphate receptor 3
Ligand
BDBM50347149
Substrate
n/a
Meas. Tech.
ChEMBL_753428 (CHEMBL1799858)
EC50
>10000±n/a nM
Citation
 Kurata, H; Kusumi, K; Otsuki, K; Suzuki, R; Kurono, M; Takada, Y; Shioya, H; Komiya, T; Mizuno, H; Ono, T; Hagiya, H; Minami, M; Nakade, S; Habashita, H Discovery of S1P agonists with a dihydronaphthalene scaffold. Bioorg Med Chem Lett 21:3885-9 (2011) [PubMed]  Article 
Target
Name:
Sphingosine 1-phosphate receptor 3
Synonyms:
C9orf108 | C9orf47 | EDG3 | Endothelial differentiation G-protein coupled receptor 3 | S1P receptor 3 | S1P receptor Edg-3 | S1P3 | S1PR3 | S1PR3_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor 3 (S1P3) | Sphingosine 1-phosphate receptor Edg-3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42278.13
Organism:
Homo sapiens (Human)
Description:
Q99500
Residue:
378
Sequence:
MATALPPRLQPVRGNETLREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMVLIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSMFVALGASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLHNLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSSSRKVANHNNSERSMALLRTVVIVVSVFIACWSPLFILFLIDVACRVQACPILFKAQWFIVLAVLNSAMNPVIYTLASKEMRRAFFRLVCNCLVRGRGARASPIQPALDPSRSKSSSSNNSSHSPKVKEDLPHTAPSSCIMDKNAALQNGIFCN
  
Inhibitor
Name:
BDBM50347149
Synonyms:
CHEMBL1797414
Type:
Small organic molecule
Emp. Form.:
C22H27NO3
Mol. Mass.:
353.4547
SMILES:
OC(=O)CCNC\C=C\c1ccc(OCCCCc2ccccc2)cc1
Structure:
Search PDB for entries with ligand similarity: