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Target
Sphingosine 1-phosphate receptor 1
Ligand
BDBM50347153
Substrate
n/a
Meas. Tech.
ChEMBL_753427 (CHEMBL1799857)
EC50
230±n/a nM
Citation
 Kurata, H; Kusumi, K; Otsuki, K; Suzuki, R; Kurono, M; Takada, Y; Shioya, H; Komiya, T; Mizuno, H; Ono, T; Hagiya, H; Minami, M; Nakade, S; Habashita, H Discovery of S1P agonists with a dihydronaphthalene scaffold. Bioorg Med Chem Lett 21:3885-9 (2011) [PubMed]  Article 
Target
Name:
Sphingosine 1-phosphate receptor 1
Synonyms:
CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1
Type:
Enzyme
Mol. Mass.:
42836.02
Organism:
Homo sapiens (Human)
Description:
P21453
Residue:
382
Sequence:
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS
  
Inhibitor
Name:
BDBM50347153
Synonyms:
CHEMBL1797502
Type:
Small organic molecule
Emp. Form.:
C23H29NO4
Mol. Mass.:
383.4807
SMILES:
COc1cc(OCCCCc2ccccc2)ccc1\C=C\CNCCC(O)=O
Structure:
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