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Target
Chitinase
Ligand
BDBM50347552
Substrate
n/a
Meas. Tech.
ChEMBL_756521 (CHEMBL1804594)
IC50
680±n/a nM
Citation
 Garner, AL; Gloeckner, C; Tricoche, N; Zakhari, JS; Samje, M; Cho-Ngwa, F; Lustigman, S; Janda, KD Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus. J Med Chem 54:3963-72 (2011) [PubMed]  Article 
Target
Name:
Chitinase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
55694.80
Organism:
Onchocerca volvulus
Description:
ChEMBL_1369100
Residue:
497
Sequence:
MRIGAMLIPFIILGNAIIAYGYVRGCYYTNWAQYRQGEGKFLPEDIPKGLCTHILYAFAKVDQSGTSLPFEWNDEDTNWSKGMYSRVTKLKENDPEMKILLSYGGYNFGSSTFTAIRNRAEKRKHFIKSAIAFLRKNKFDGFDFDWEYPIGMAQEYAKLVNEMKVAFVEEAKKSDSEQLLLTAAVSAGKHTIDQSYNVQSLGENFDLLSLMSYDFHGSWEMNVDLHAKLHPTKGETSGTGIFNTEFAANYWLSKGMPKQKIIIGIPTYGRGWTLRDSSKTTIGAEGISPSSPSTTNPAGGTAAYWEICKYLKEGGKETIDEQGVGACMVQGSQWYGYDNEETIRMKMRWLKEKGYGGAFIWTLDFDDFKGTSCGEGPYPLLSAINHELKGEATATTRSLRTTITQSSTIGSTKFETTTTASEITKNNKIKTTTIAVEPTGESSDIKCPESFGLFRHPNDCHLFIHCAHDHPYVKLCPPNTFFNDKIKVCDHFGECDE
  
Inhibitor
Name:
BDBM50347552
Synonyms:
CHEMBL391125
Type:
Small organic molecule
Emp. Form.:
C13H8BrI2NO2
Mol. Mass.:
543.921
SMILES:
Oc1c(I)cc(I)cc1C(=O)Nc1ccc(Br)cc1
Structure:
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