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Target
Interferon-induced, double-stranded RNA-activated protein kinase
Ligand
BDBM50162083
Substrate
n/a
Meas. Tech.
ChEMBL_756675 (CHEMBL1805140)
IC50
15000±n/a nM
Citation
 Bryk, R; Wu, K; Raimundo, BC; Boardman, PE; Chao, P; Conn, GL; Anderson, E; Cole, JL; Duffy, NP; Nathan, C; Griffin, JH Identification of new inhibitors of protein kinase R guided by statistical modeling. Bioorg Med Chem Lett 21:4108-14 (2011) [PubMed]  Article 
Target
Name:
Interferon-induced, double-stranded RNA-activated protein kinase
Synonyms:
E2AK2_HUMAN | EIF2AK2 | Eukaryotic translation initiation factor 2-alpha kinase 2 | Interferon-inducible RNA-dependent protein kinase | P1/eIF-2A protein kinase | PKR | PRKR | Protein kinase R | Protein kinase RNA-activated | Tyrosine-protein kinase EIF2AK2 | eIF-2A protein kinase 2 | p68 kinase
Type:
PROTEIN
Mol. Mass.:
62104.61
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1467743
Residue:
551
Sequence:
MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSKKEAKNAAAKLAVEILNKEKKAVSPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLTVNYEQCASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSGSFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAKRSLAPRFDLPDMKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC
  
Inhibitor
Name:
BDBM50162083
Synonyms:
(5-Methyl-1H-pyrazol-3-yl)-(2-phenyl-quinazolin-4-yl)-amine | (5-Methyl-1H-pyrazol-3-yl)-(2-phenylquinazolin-4-yl)amine | CHEMBL359482 | N-(3-methyl-1H-pyrazol-5-yl)-2-phenylquinazolin-4-amine | N-(5-METHYL-1H-PYRAZOL-3-YL)-2-PHENYLQUINAZOLIN-4-AMINE
Type:
Small organic molecule
Emp. Form.:
C18H15N5
Mol. Mass.:
301.3452
SMILES:
Cc1cc(Nc2nc(nc3ccccc23)-c2ccccc2)[nH]n1
Structure:
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