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Target
3-oxoacyl-[acyl-carrier-protein] synthase 3
Ligand
BDBM50349507
Substrate
n/a
Meas. Tech.
ChEMBL_759514 (CHEMBL1810955)
IC50
3300±n/a nM
Citation
 Li, HQ; Luo, Y; Zhu, HL Discovery of vinylogous carbamates as a novel class ofß-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors. Bioorg Med Chem 19:4454-9 (2011) [PubMed]  Article 
Target
Name:
3-oxoacyl-[acyl-carrier-protein] synthase 3
Synonyms:
3-oxoacyl-[acyl-carrier-protein] synthase | 3-oxoacyl-[acyl-carrier-protein] synthase 3 | 3-oxoacyl-[acyl-carrier-protein] synthase III | Beta-ketoacyl-ACP synthase III (FabH)
Type:
Enzyme
Mol. Mass.:
33506.68
Organism:
Escherichia coli
Description:
C3TDZ2
Residue:
317
Sequence:
MYTKIIGTGSYLPEQVRTNADLEKMVDTSDEWIVTRTGIRERHIAAPNETVSTMGFEAATRAIEMAGIEKDQIGLIVVATTSATHAFPSAACQIQSMLGIKGCPAFDVAAACAGFTYALSVADQYVKSGAVKYALVVGSDVLARTCDPTDRGTIIIFGDGAGAAVLAASEEPGIISTHLHADGSYGELLTLPNADRVNPENSIHLTMAGNEVFKVAVTELAHIVDETLAANNLDRSQLDWLVPHQANLRIISATAKKLGMSMDNVVVTLDRHGNTSAASVPCALDEAVRDGRIKPGQLVLLEAFGGGFTWGSALVRF
  
Inhibitor
Name:
BDBM50349507
Synonyms:
CHEMBL1808651 | CHEMBL1808652
Type:
Small organic molecule
Emp. Form.:
C24H22BrNO3
Mol. Mass.:
452.34
SMILES:
CCOC(=O)C(C=Nc1ccc(Br)cc1)c1ccc(OCc2ccccc2)cc1 |w:7.7|
Structure:
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