Reaction Details Report a problem with these data
Target
Polyunsaturated fatty acid lipoxygenase ALOX15B
Ligand
BDBM64674
Substrate
n/a
Meas. Tech.
ChEMBL_761396 (CHEMBL1817026)
IC50
>100000±n/a nM
Citation
Kenyon, V; Rai, G; Jadhav, A; Schultz, L; Armstrong, M; Jameson, JB; Perry, S; Joshi, N; Bougie, JM; Leister, W; Taylor-Fishwick, DA; Nadler, JL; Holinstat, M; Simeonov, A; Maloney, DJ; Holman, TR Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase. J Med Chem 54:5485-97 (2011) [PubMed] Article
More Info.:
Target
Name:
Polyunsaturated fatty acid lipoxygenase ALOX15B
Synonyms:
15-LOX-2 | 15-Lipo-oxygenase type 2 (15-LOX-2) | 15-Lipoxygenase-2 (15-LOX-2) | 15-lipoxygenase 2 | ALOX15B | Arachidonate 15-lipoxygenase type II | Arachidonate 15-lipoxygenase, type II | Arachidonate 15-lipoxygenase-2 | Epithelial 15-lipoxygenase-2 | LX15B_HUMAN
Type:
Protein
Mol. Mass.:
75850.40
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
676
Sequence:
MAEFRVRVSTGEAFGAGTWDKVSVSIVGTRGESPPLPLDNLGKEFTAGAEEDFQVTLPEDVGRVLLLRVHKAPPVLPLLGPLAPDAWFCRWFQLTPPRGGHLLFPCYQWLEGAGTLVLQEGTAKVSWADHHPVLQQQRQEELQARQEMYQWKAYNPGWPHCLDEKTVEDLELNIKYSTAKNANFYLQAGSAFAEMKIKGLLDRKGLWRSLNEMKRIFNFRRTPAAEHAFEHWQEDAFFASQFLNGLNPVLIRRCHYLPKNFPVTDAMVASVLGPGTSLQAELEKGSLFLVDHGILSGIQTNVINGKPQFSAAPMTLLYQSPGCGPLLPLAIQLSQTPGPNSPIFLPTDDKWDWLLAKTWVRNAEFSFHEALTHLLHSHLLPEVFTLATLRQLPHCHPLFKLLIPHTRYTLHINTLARELLIVPGQVVDRSTGIGIEGFSELIQRNMKQLNYSLLCLPEDIRTRGVEDIPGYYYRDDGMQIWGAVERFVSEIIGIYYPSDESVQDDRELQAWVREIFSKGFLNQESSGIPSSLETREALVQYVTMVIFTCSAKHAAVSAGQFDSCAWMPNLPPSMQLPPPTSKGLATCEGFIATLPPVNATCDVILALWLLSKEPGDQRPLGTYPDEHFTEEAPRRSIATFQSRLAQISRGIQERNQGLVLPYTYLDPPLIENSVSI
Inhibitor
Name:
BDBM64674
Synonyms:
MLS000713956 | N-[(5-chloranyl-8-oxidanyl-quinolin-7-yl)-(furan-2-yl)methyl]propanamide | N-[(5-chloro-8-hydroxy-7-quinolinyl)-(2-furanyl)methyl]propanamide | N-[(5-chloro-8-hydroxy-7-quinolyl)-(2-furyl)methyl]propionamide | N-[(5-chloro-8-hydroxyquinolin-7-yl)-(furan-2-yl)methyl]propanamide | SMR000273437 | cid_2920571
Type:
Small organic molecule
Emp. Form.:
C17H15ClN2O3
Mol. Mass.:
330.766
SMILES:
CCC(=O)NC(c1ccco1)c1cc(Cl)c2cccnc2c1O