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Target
Transcriptional activator protein LasR
Ligand
BDBM50266198
Substrate
n/a
Meas. Tech.
ChEMBL_765283 (CHEMBL1827922)
IC50
4670±n/a nM
Citation
 Lowery, CA; Salzameda, NT; Sawada, D; Kaufmann, GF; Janda, KD Medicinal chemistry as a conduit for the modulation of quorum sensing. J Med Chem 53:7467-89 (2010) [PubMed]  Article 
Target
Name:
Transcriptional activator protein LasR
Synonyms:
LASR_PSEAE | lasR
Type:
PROTEIN
Mol. Mass.:
26618.24
Organism:
Pseudomonas aeruginosa
Description:
ChEMBL_1475312
Residue:
239
Sequence:
MALVDGFLELERSSGKLEWSAILQKMASDLGFSKILFGLLPKDSQDYENAFIVGNYPAAWREHYDRAGYARVDPTVSHCTQSVLPIFWEPSIYQTRKQHEFFEEASAAGLVYGLTMPLHGARGELGALSLSVEAENRAEANRFMESVLPTLWMLKDYALQSGAGLAFEHPVSKPVVLTSREKEVLQWCAIGKTSWEISVICNCSEANVNFHMGNIRRKFGVTSRRVAAIMAVNLGLITL
  
Inhibitor
Name:
BDBM50266198
Synonyms:
(S)-N-(2-oxotetrahydrofuran-3-yl)-2-(4-(trifluoromethoxy)phenoxy)acetamide | CHEMBL503197
Type:
Small organic molecule
Emp. Form.:
C13H12F3NO5
Mol. Mass.:
319.2333
SMILES:
FC(F)(F)Oc1ccc(OCC(=O)N[C@H]2CCOC2=O)cc1 |r|
Structure:
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