| Reaction Details |
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 | Report a problem with these data |
| Target | TGF-beta receptor type-1 |
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| Ligand | BDBM50351818 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_765279 |
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| IC50 | >1000±n/a nM |
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| Citation |  Jin, CH; Sreenu, D; Krishnaiah, M; Subrahmanyam, VB; Rao, KS; Nagendra Mohan, AV; Park, CY; Son, JY; Son, DH; Park, HJ; Sheen, YY; Kim, DK Synthesis and biological evaluation of 1-substituted-3(5)-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)pyrazoles as transforming growth factor-ß type 1 receptor kinase inhibitors. Eur J Med Chem46:3917-25 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| TGF-beta receptor type-1 |
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| Name: | TGF-beta receptor type-1 |
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| Synonyms: | ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TbetaR-I | Transforming growth factor-beta receptor type I |
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| Type: | enzyme |
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| Mol. Mass.: | 55968.24 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P36897 |
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| Residue: | 503 |
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| Sequence: | MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTE
TTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPG
LGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDL
IYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREER
SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVE
GMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS
ATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGI
HEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGA
ARLTALRIKKTLSQLSQQEGIKM
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| BDBM50351818 |
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| Name | BDBM50351818 |
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| Synonyms: | CHEMBL1824438 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H22N6O |
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| Mol. Mass. | 434.4925 |
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| SMILES | Cc1cccc(n1)-c1nn(CCC(=O)Nc2ccccc2)cc1-c1ccc2nccnc2c1 |
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| Structure | 
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| n/a |
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