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Target
Aurora kinase B
Ligand
BDBM50352316
Substrate
n/a
Meas. Tech.
ChEMBL_766655 (CHEMBL1827221)
IC50
51±n/a nM
Citation
 Abraham, S; Hadd, MJ; Tran, L; Vickers, T; Sindac, J; Milanov, ZV; Holladay, MW; Bhagwat, SS; Hua, H; Ford Pulido, JM; Cramer, MD; Gitnick, D; James, J; Dao, A; Belli, B; Armstrong, RC; Treiber, DK; Liu, G Novel series of pyrrolotriazine analogs as highly potent pan-Aurora kinase inhibitors. Bioorg Med Chem Lett 21:5296-300 (2011) [PubMed]  Article 
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Inhibitor
Name:
BDBM50352316
Synonyms:
CHEMBL1822660
Type:
Small organic molecule
Emp. Form.:
C28H26F2N8O3S
Mol. Mass.:
592.62
SMILES:
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4C[C@H](O)[C@H](C4)Oc4cc(F)cc(F)c4)cc3)nn3cccc23)n[nH]1 |r|
Structure:
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