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Target
Sodium-dependent serotonin transporter
Ligand
BDBM50352696
Substrate
n/a
Meas. Tech.
ChEMBL_766795 (CHEMBL1827735)
IC50
19±n/a nM
Citation
 Seo, HJ; Park, EJ; Kim, MJ; Kang, SY; Lee, SH; Kim, HJ; Lee, KN; Jung, ME; Lee, M; Kim, MS; Son, EJ; Park, WK; Kim, J; Lee, J Design and synthesis of novel arylpiperazine derivatives containing the imidazole core targeting 5-HT(2A) receptor and 5-HT transporter. J Med Chem 54:6305-18 (2011) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4
Type:
Multi-pass membrane protein
Mol. Mass.:
70322.51
Organism:
Homo sapiens (Human)
Description:
P31645
Residue:
630
Sequence:
METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETPTEIPCGDIRLNAV
  
Inhibitor
Name:
BDBM50352696
Synonyms:
CHEMBL1823184
Type:
Small organic molecule
Emp. Form.:
C27H34ClN5O3
Mol. Mass.:
512.044
SMILES:
COc1ccccc1-n1c(C)nc(C(=O)NCC(O)CN2CCN(CC2)c2cccc(Cl)c2C)c1C |(-6.15,-25.82,;-6.16,-27.36,;-7.49,-28.12,;-8.83,-27.35,;-10.17,-28.12,;-10.17,-29.67,;-8.83,-30.43,;-7.5,-29.66,;-6.17,-30.43,;-5.69,-31.9,;-6.47,-33.23,;-4.15,-31.9,;-3.67,-30.43,;-2.34,-29.66,;-2.34,-28.12,;-1.01,-30.43,;.33,-29.66,;1.66,-30.43,;1.66,-31.97,;2.99,-29.66,;4.32,-30.43,;5.65,-29.65,;6.98,-30.41,;6.99,-31.95,;5.65,-32.73,;4.31,-31.96,;8.32,-32.72,;9.65,-31.94,;10.99,-32.7,;10.99,-34.25,;9.65,-35.02,;9.65,-36.56,;8.32,-34.25,;6.99,-35.02,;-4.92,-29.52,;-4.93,-27.98,)|
Structure:
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