Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50353159
Substrate
n/a
Meas. Tech.
ChEMBL_768586 (CHEMBL1832605)
Ki
14±n/a nM
Citation
 Wu, L; Lu, K; Desai, M; Packiarajan, M; Joshi, A; Marzabadi, MR; Jubian, V; Andersen, K; Chandrasena, G; Boyle, NJ; Walker, MW N-Heteroaryl glycinamides and glycinamines as potent NPY5 antagonists. Bioorg Med Chem Lett 21:5573-6 (2011) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50353159
Synonyms:
CHEMBL1829331
Type:
Small organic molecule
Emp. Form.:
C20H32ClN3O3S
Mol. Mass.:
430.004
SMILES:
CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)NCCN1CCOc2cc(Cl)ccc12 |r,wU:8.7,wD:11.14,(10.45,-.43,;9.12,.34,;9.12,1.88,;7.78,-.43,;7,-1.75,;8.54,-1.75,;6.45,.35,;5.11,-.42,;3.78,.35,;2.45,-.41,;1.12,.36,;1.12,1.9,;2.45,2.67,;3.78,1.9,;-.21,2.66,;-1.55,1.89,;-2.88,2.66,;-4.21,1.89,;-4.22,.35,;-5.55,-.42,;-6.88,.35,;-6.88,1.88,;-8.22,2.65,;-8.22,4.19,;-9.55,4.96,;-6.89,4.96,;-5.55,4.2,;-5.55,2.65,)|
Structure:
Search PDB for entries with ligand similarity: