Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase Sgk3
Ligand
BDBM60665
Substrate
n/a
Meas. Tech.
ChEMBL_774553 (CHEMBL1908770)
Kd
>10000±n/a nM
Citation
 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol 29:1046-51 (2011) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Sgk3
Synonyms:
CISK | Cytokine-independent survival kinase | SGK3 | SGK3_HUMAN | SGKL | Serum/glucocorticoid-regulated kinase 3 | Serum/glucocorticoid-regulated kinase-like
Type:
PROTEIN
Mol. Mass.:
57110.99
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1445194
Residue:
496
Sequence:
MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNTLKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDLFL
  
Inhibitor
Name:
BDBM60665
Synonyms:
BDBM50249542 | US9145414, R406 | US9212178, R406
Type:
n/a
Emp. Form.:
C22H23FN6O5
Mol. Mass.:
470.4536
SMILES:
COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4n3)n2)cc(OC)c1OC
Structure:
Search PDB for entries with ligand similarity: