Target
Serine/threonine-protein kinase Chk1
Ligand
BDBM50355601
Substrate
n/a
Meas. Tech.
ChEMBL_776689 (CHEMBL1913786)
IC50
>100000±n/a nM
Citation
 Andreani, AGranaiola, MLeoni, ALocatelli, AMorigi, RRambaldi, MVaroli, LLannigan, DSmith, JScudiero, DKondapaka, SShoemaker, RH Imidazo[2,1-b]thiazole guanylhydrazones as RSK2 inhibitors. Eur J Med Chem 46:4311-23 (2011) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Chk1
Synonyms:
CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54443.02
Organism:
Homo sapiens (Human)
Description:
gi_166295192
Residue:
476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
  
Inhibitor
Name:
BDBM50355601
Synonyms:
CHEMBL1910755
Type:
Small organic molecule
Emp. Form.:
C12H10Cl2N6S2
Mol. Mass.:
373.284
SMILES:
Cc1cn2c(\C=N\NC(N)=N)c(nc2s1)-c1cc(Cl)sc1Cl
Structure:
Search PDB for entries with ligand similarity: