Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM50356547
Substrate
n/a
Meas. Tech.
ChEMBL_776031 (CHEMBL1912501)
Ki
53.9±n/a nM
Citation
 Piscitelli, F; Ligresti, A; La Regina, G; Gatti, V; Brizzi, A; Pasquini, S; Allarà, M; Carai, MA; Novellino, E; Colombo, G; Di Marzo, V; Corelli, F; Silvestri, R 1-Aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide: an effective scaffold for the design of either CB1 or CB2 receptor ligands. Eur J Med Chem 46:5641-53 (2011) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM50356547
Synonyms:
CHEMBL1909855
Type:
Small organic molecule
Emp. Form.:
C22H15Cl5N4O
Mol. Mass.:
528.646
SMILES:
Cc1c(nn(c1-n1cccc1Cl)-c1ccc(Cl)c(Cl)c1)C(=O)NCc1ccc(Cl)c(Cl)c1 |(-6.94,-37.02,;-6.03,-38.27,;-4.49,-38.27,;-4.02,-39.73,;-5.27,-40.63,;-6.51,-39.73,;-7.98,-40.18,;-8.48,-41.64,;-10.02,-41.61,;-10.48,-40.14,;-9.22,-39.25,;-9.19,-37.71,;-5.27,-42.17,;-6.61,-42.94,;-6.61,-44.48,;-5.28,-45.25,;-5.28,-46.8,;-3.94,-44.48,;-2.6,-45.24,;-3.94,-42.94,;-3.59,-37.02,;-4.21,-35.61,;-2.05,-37.19,;-1.15,-35.94,;.39,-35.92,;1.17,-37.25,;2.7,-37.24,;3.46,-35.9,;5,-35.88,;2.67,-34.57,;3.42,-33.23,;1.14,-34.59,)|
Structure:
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