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Target
Histamine H4 receptor
Ligand
BDBM50356831
Substrate
n/a
Meas. Tech.
ChEMBL_786095 (CHEMBL1919838)
Ki
33±n/a nM
Citation
 Savall, BM; Gomez, L; Chavez, F; Curtis, M; Meduna, SP; Kearney, A; Dunford, P; Cowden, J; Thurmond, RL; Grice, C; Edwards, JP Tricyclic aminopyrimidine histamine H4 receptor antagonists. Bioorg Med Chem Lett 21:6577-81 (2011) [PubMed]  Article 
Target
Name:
Histamine H4 receptor
Synonyms:
AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44517.02
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:
390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
  
Inhibitor
Name:
BDBM50356831
Synonyms:
CHEMBL1915020
Type:
Small organic molecule
Emp. Form.:
C15H16ClN5S
Mol. Mass.:
333.839
SMILES:
CN[C@H]1CCN(C1)c1nc(N)nc2c3ccc(Cl)cc3sc12 |r|
Structure:
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