Target
Histamine H4 receptor
Ligand
BDBM50356854
Substrate
n/a
Meas. Tech.
ChEMBL_786095 (CHEMBL1919838)
Ki
>10000±n/a nM
Citation
 Savall, BMGomez, LChavez, FCurtis, MMeduna, SPKearney, ADunford, PCowden, JThurmond, RLGrice, CEdwards, JP Tricyclic aminopyrimidine histamine H4 receptor antagonists. Bioorg Med Chem Lett 21:6577-81 (2011) [PubMed]  Article 
Target
Name:
Histamine H4 receptor
Synonyms:
AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44517.02
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:
390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
  
Inhibitor
Name:
BDBM50356854
Synonyms:
CHEMBL1915043
Type:
Small organic molecule
Emp. Form.:
C16H14F3N5S
Mol. Mass.:
365.376
SMILES:
Nc1nc(N2C[C@@H]3C[C@H]2CN3)c2sc3cc(ccc3c2n1)C(F)(F)F |r|
Structure:
Search PDB for entries with ligand similarity: