Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50357453
Substrate
n/a
Meas. Tech.
ChEMBL_788478 (CHEMBL1918281)
Ki
0.7±n/a nM
Citation
 Rossi, D; Pedrali, A; Urbano, M; Gaggeri, R; Serra, M; Fernández, L; Fernández, M; Caballero, J; Ronsisvalle, S; Prezzavento, O; Schepmann, D; Wuensch, B; Peviani, M; Curti, D; Azzolina, O; Collina, S Identification of a potent and selectives¿? receptor agonist potentiating NGF-induced neurite outgrowth in PC12 cells. Bioorg Med Chem 19:6210-24 (2011) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50357453
Synonyms:
CHEMBL1917719
Type:
Small organic molecule
Emp. Form.:
C21H27N
Mol. Mass.:
293.4458
SMILES:
CC(CCN1CCCCC1)c1ccc(cc1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: