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Target
Monoglyceride lipase
Ligand
BDBM60622
Substrate
n/a
Meas. Tech.
ChEMBL_787763 (CHEMBL1918442)
IC50
8±n/a nM
Citation
 Szabo, M; Agostino, M; Malone, DT; Yuriev, E; Capuano, B The design, synthesis and biological evaluation of novel URB602 analogues as potential monoacylglycerol lipase inhibitors. Bioorg Med Chem Lett 21:6782-7 (2011) [PubMed]  Article 
Target
Name:
Monoglyceride lipase
Synonyms:
MAG lipase | MGLL_MOUSE | Mgll | Monoacylglycerol lipase | Monoglyceride Lipase (MGL)
Type:
Hydrolase
Mol. Mass.:
33391.67
Organism:
Mus musculus (mouse)
Description:
Assays were using membranes of recombinant MAG Lipase transiently transfected in COS-7 cells.
Residue:
303
Sequence:
MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDELAHMLKGLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDVLQHVDTIQKDYPDVPIFLLGHSMGGAISILVAAERPTYFSGMVLISPLVLANPESASTLKVLAAKLLNFVLPNMTLGRIDSSVLSRNKSEVDLYNSDPLVCRAGLKVCFGIQLLNAVARVERAMPRLTLPFLLLQGSADRLCDSKGAYLLMESSRSQDKTLKMYEGAYHVLHRELPEVTNSVLHEVNSWVSHRIAAAGAGCPP
  
Inhibitor
Name:
BDBM60622
Synonyms:
BDBM50300355 | US11753371, Compound JZL-184 | US9133148, A
Type:
n/a
Emp. Form.:
C27H24N2O9
Mol. Mass.:
520.4875
SMILES:
OC(C1CCN(CC1)C(=O)Oc1ccc(cc1)[N+]([O-])=O)(c1ccc2OCOc2c1)c1ccc2OCOc2c1
Structure:
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