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Target
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
Ligand
BDBM21434
Substrate
n/a
Meas. Tech.
ChEMBL_785939 (CHEMBL1921249)
Ki
>10000±n/a nM
Citation
 Goreshnik, I; Brock, AM; Maly, DJ Biochemical and pharmacological profiling of the pro-survival protein Bcl-xL. Bioorg Med Chem Lett 21:4951-5 (2011) [PubMed]  Article 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
Synonyms:
Bcl-2-related protein EAT/mcl1 | MCL1_MOUSE | Mcl-1 | Mcl1
Type:
Developmental protein
Mol. Mass.:
35215.08
Organism:
Mus musculus (Mouse)
Description:
n/a
Residue:
331
Sequence:
MFGLRRNAVIGLNLYCGGASLGAGGGSPAGARLVAEEAKARREGGGEAALLPGARVVARPPPVGAEDPDVTASAERRLHKSPGLLAVPPEEMAASAAAAIVSPEEELDGCEPEAIGKRPAVLPLLERVSEAAKSSGADGSLPSTPPPPEEEEDDLYRQSLEIISRYLREQATGSKDSKPLGEAGAAGRRALETLRRVGDGVQRNHETAFQGMLRKLDIKNEGDVKSFSRVMVHVFKDGVTNWGRIVTLISFGAFVAKHLKSVNQESFIEPLAETITDVLVRTKRDWLVKQRGWDGFVEFFHVQDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM21434
Synonyms:
N-Benylpiperazine derivative, 23j | N-[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrobenzene)sulfonyl]-4-(4-{[2-(trifluoromethyl)phenyl]methyl}piperazin-1-yl)benzamide
Type:
Small organic molecule
Emp. Form.:
C37H41F3N6O5S2
Mol. Mass.:
770.884
SMILES:
CN(C)CC[C@H](CSc1ccccc1)Nc1ccc(cc1[N+]([O-])=O)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCN(Cc2ccccc2C(F)(F)F)CC1 |r|
Structure:
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