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Target
Appetite-regulating hormone
Ligand
BDBM50359238
Substrate
n/a
Meas. Tech.
ChEMBL_790253 (CHEMBL1925646)
Ki
4.80±n/a nM
Citation
 Hoveyda, HR; Marsault, E; Gagnon, R; Mathieu, AP; Vézina, M; Landry, A; Wang, Z; Benakli, K; Beaubien, S; Saint-Louis, C; Brassard, M; Pinault, JF; Ouellet, L; Bhat, S; Ramaseshan, M; Peng, X; Foucher, L; Beauchemin, S; Bhérer, P; Veber, DF; Peterson, ML; Fraser, GL Optimization of the potency and pharmacokinetic properties of a macrocyclic ghrelin receptor agonist (Part I): Development of ulimorelin (TZP-101) from hit to clinic. J Med Chem 54:8305-20 (2011) [PubMed]  Article 
Target
Name:
Appetite-regulating hormone
Synonyms:
GHRL | GHRL_HUMAN | Ghrelin | Ghrelin-27 | Ghrelin-28 | Growth hormone secretagogue | Growth hormone-releasing peptide | MTLRP | Motilin-related peptide | Obestatin | Protein M46
Type:
PROTEIN
Mol. Mass.:
12908.57
Organism:
Homo sapiens (Human)
Description:
ChEMBL_790253
Residue:
117
Sequence:
MPSPGTVCSLLLLGMLWLDLAMAGSSFLSPEHQRVQQRKESKKPPAKLQPRALAGWLRPEDGGQAEGAEDELEVRFNAPFDVGIKLSGVQYQQHSQALGKFLQDILWEEAKEAPADK
  
Inhibitor
Name:
BDBM50359238
Synonyms:
CHEMBL1923628
Type:
Small organic molecule
Emp. Form.:
C31H41FN4O4
Mol. Mass.:
552.68
SMILES:
C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)c(C)c2)C(=O)NCCCc2ccccc2O1 |r|
Structure:
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