Reaction Details Report a problem with these data
Target
Lysosomal acid glucosylceramidase
Ligand
BDBM50360268
Substrate
n/a
Meas. Tech.
ChEMBL_796390 (CHEMBL1937705)
IC50
244000±n/a nM
Citation
 Deschamp, J; Mondon, M; Nakagawa, S; Kato, A; Alonzi, DS; Butters, TD; Zhang, Y; Sollogoub, M; Blériot, Y Towards a stable noeuromycin analog with a D-manno configuration: synthesis and glycosidase inhibition of D-manno-like tri- and tetrahydroxylated azepanes. Bioorg Med Chem 20:641-9 (2012) [PubMed]  Article 
Target
Name:
Lysosomal acid glucosylceramidase
Synonyms:
Acid beta-glucosidase | D-glucosyl-N-acylsphingosine glucohydrolase | GBA | GBA1 | GBA1_BOVIN | Glucosylceramidase
Type:
PROTEIN
Mol. Mass.:
59862.93
Organism:
Bos taurus
Description:
ChEMBL_1460504
Residue:
536
Sequence:
MELSSPSREEYPMPRGRVGIMAASLMGLLLLHTVSWVSGARPCSPKSFGYSSVVCVCNGTYCDSLDPLTLPDPGTFSRFESTRSGRRMELSLGTIQANRTGTGLLLTLQPDQKFQKVKGFGGAMTDAAALNILALSPAARNLLLKSYFSEEGIEYNIIRVPMASCDFSIRTYTYDDSPDDFQLLNFSLPEEDVKLKIPLIHQALELANRSVSLFASPWTSPTWLKTNGAVNGKGTLKGQAGDLYHKTWARYFVKFLDAYAEHKLRFWAVTAENEPTAGLLTGYPFQCLGFTPEHQRDFIARDLGPILANSTHRDVRLLMLDDQRLLLPRWAQVVLADPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMRYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDIAKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASKKSDLDTVALLRPDGSAVAVVLNRSSKDVPLTIKDPAVGFMETVSPGYSIHTYLWRRQ
  
Inhibitor
Name:
BDBM50360268
Synonyms:
CHEMBL1933098
Type:
Small organic molecule
Emp. Form.:
C7H15NO3
Mol. Mass.:
161.1989
SMILES:
C[C@@H]1CNC[C@@H](O)[C@@H](O)[C@@H]1O |r|
Structure:
Search PDB for entries with ligand similarity: